Dev122390 1293..1298
نویسندگان
چکیده
The developing forebrain roof plate (RP) contains a transient signaling center, perturbations in which have been linked to holoprosencephaly (HPE). Here, we describe a novel domain of retinoic acid (RA) signaling that is specific to the chick RP and demonstrate that RA signaling is sufficient for inducing characteristics of the RP in ectopic locations. We further demonstrate that, unlike what has been observed in the mouse, RA signaling is essential for invagination of the RP in chick, failure of which leads to an HPE-like phenotype. In addition, we found that RA exerts a negative influence on choroid plexus differentiation. Thus, our findings identify RA as a novel regulator of chick forebrain RP development.
منابع مشابه
Raman microspectrometry applied to the study of electrode materials for lithium batteries.
4.3. Manganese Oxide-Based Compounds 1291 4.3.1. MnO2-Type Compounds 1291 4.3.2. Ternary Lithiated LixMnOy Compounds 1293 4.4. Vanadium Pentoxide V2O5 1298 4.4.1. V2O5 Structure 1298 4.4.2. LixV2O5 Bulk Phases 1300 4.4.3. LixV2O5 Crystallized Thin Films 1303 4.5. Titanium Oxide-Based Compounds 1305 4.5.1. Lithium Titanate Li4Ti5O12 1306 4.5.2. TiO2 Anatase 1308 5. Phospho-olivine LiFePO4 Compou...
متن کاملFiduciary Law in the Twenty-first Century
INTRODUCTION ............................................................................................. 1289 I. THE NATURE AND COMPONENTS OF FIDUCIARY RELATIONSHIPS AND THE RISKS THE RELATIONSHIPS POSE TO BOTH PARTIES .......... 1293 A. Components of Fiduciary Relationships .................................... 1293 B. While Fiduciaries’ Services Provide Benefits to Entrustors, the Services I...
متن کاملThe carbohydrate-deficient glycoprotein syndrome: an experiment of nature in glycosylation.
1808-1814 41 Soliday, C. L. and Kolattukudy, 1’. E. (1979) Arch. Riochem. Biophys. 197,367-378 42 Gander, J. E., Drewes, L. R., Fang, F. and h i , A. (1977) J. Biol. Chem. 252,2187-2193 43 Speake, B. K., Malley, D. J. and Hemming, F. W. (1981) Arch. Biochem. Biophys. 210, 110-1 13 44 Kruszewska. J., Messner, R., Kubicek, C. 1’. and Palamarczyk, G. (1989) J. Gen. Microbiol. 135, 301-307 45 Krusz...
متن کاملتلاشهای سیدضیاءالدین طباطبایی در ایجاد کنفدراسیون میان ایران و آذربایجان (روسیه) 24 دی 1298
این مقاله پیرامون تلاش های دیپلماتیک سیدضیاءالدین طباطبایی می باشد که در رأس یک هیأت رسمی از سوی دولت ایران در سال 1298 (هجری شمسی) به منطقه قفقاز اعزام شده است. این هیأت بلندپایه دیپلماتیک زمانی به قفقاز اعزام شده است که منطقه در تب و تاب تغییر و تحولات سیاسی و اجتماعی به سر می برد. امپراتوری بزرگ روسیه همسایه شمالی ایران و یکی از نیرومندترین قدرت‌های جهانی به سرعت در حال فروپاشی است. جنگ جهان...
متن کاملRegional Cortical Blood Flow
We conducted regional cortical blood flow studies using the xenon-133 clearance technique on 12 volunteers during the administration of 25% and 50% N2O and during baseline conditions (breathing room air or 100% O2). Global cortical blood flow was very highly significantly increased above baseline measures in all subjects by 50% N2O (mean increase 37% above 100% O2 condition). A smaller but stil...
متن کامل